MAPPING HUMAN DISEASE-ASSOCIATED ENZYMES INTO REACTOME ALLOWS CHARACTERIZATION OF DISEASE GROUPS AND THEIR INTERACTIONS

Mapping human disease-associated enzymes into Reactome allows characterization of disease groups and their interactions

Abstract According to databases such as OMIM, Humsavar, Clinvar and Monarch, 1494 human enzymes are presently associated to 2539 genetic Insulated Covers diseases, 75% of which are rare (with an Orphanet code).The Mondo ontology initiative allows a standardization of the disease name into specific codes, making it possible a computational associati

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High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

Rajesh Mukthavaram,1 Pengfei Jiang,1 Rohit Saklecha,1 Dmitri Simberg,3,4 Ila Sri Bharati,1 Natsuko Nomura,1 Ying Chao,1 Sandra Pastorino,1 Sandeep C Pingle,1 Valentina Fogal,1 Wolf Wrasidlo,1,2 Milan Makale,1,2 Santosh Kesari1,21Translational Neuro-Oncology Laboratories, 2Department of Neurosciences, 3Solid Tumor Therapeutics Program, Moores Cancer

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